I am the (currently not so proud) owner of a Logitech 250 USB headset that gives my patience a run for its money. Whenever I revive my Mac Book Pro (first generation core duo) and plug the USB headset into one of the USB ports, OS X grinds to a halt.
I'm not the only one who faces this problem. I can attest to the experience in that support discussion: it doesn't matter in which USB port I plug the headset, or even if it is linked through my cinema display's USB hub. The only thing I can add is that this happens when my mac book has been asleep.
Last time I complained on this blog about a thing that bugged me on OS X, it got resolved pretty quickly, so here's hoping for us Logitech 250 owners!